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--- proiecte:microsal [2017/02/09 17:05]
adrian.nitu
+++ proiecte:microsal [2017/03/27 19:13] (current)
adrian.nitu [UI improve]
@@ Line 2: / Line 2: @@
 ====== Microsal ======
-[[mail:adrian.nitu.92.at.gmail|**Nițu Adrian** - SRIC]]
+**[[mail:adrian.nitu.92.at.gmail|Nițu Adrian - SRIC]]**
 Dental Implant With Contact Nano-Sensors for the Treatment of Xerostomia
-Microsal represents the collaboration of multiple faculties with the purpose to create a **micro-embedded device** meant to alleviate symptoms of [[https://en.wikipedia.org/wiki/Xerostomia|xerostomia]] and also collect patient data regarding the condition in an unobstrusive way.
+Microsal represents the collaboration of multiple faculties with the purpose to create a third generation **micro-embedded device** meant to alleviate symptoms of [[https://en.wikipedia.org/wiki/Xerostomia|xerostomia]] and also collect patient data regarding the condition in an unobstrusive way.
-The current iteration of this project has already been investigated in a diploma project and already presented at an embedded devices conference[2] and at a medical workshop [1] with plans to demonstrate crrent research stages.
+The current iteration of this project has already been investigated in a diploma project and already presented at an embedded devices conference and at a medical workshop with plans to demonstrate crrent research stages.
 This chapter will describe the current iteration and some of the design choices.
 Microsal represents the research efforts of multiple faculties to create a third-generation implant-supported neuro-electrostimulation embedded device. This research report will only report on the hardware/firmware/software details regarding the project. As described in the related work section, the device’s main goal is to electrically stimulate the bucal and lingual nerve in order to produce the salivary response and increase the comfort of the patient. Additionally, besides the stimulation logic, the design also includes 2 passive sensors that are used to objectively evaluate the current conditions of the patient.
 The information taken from the sensors will be used to determine if the patient’s condition is deteriorating or improving over time, providing valuable insight on the effectiveness of the treatment. This represents the next logical step for the evolution of the generational prototypes. Also, to facilitate communication to the device we have decided to use a chip that has a Bluetooth Low Energy component integrated inside. The NRF51822 chip, by Nordic Semiconductors fits the bill, being a highly advanced ARM microcontroller, with BLE functionality and extremely low power requirements
-The high level design is described in Fig \ref{fig:design
+The high level design is described in the design figures
 {{:proiecte:microsal:big.jpg?direct&100|}}
 {{:proiecte:microsal:small.png?direct&100|}}
 Relative size of the embedded device
 {{:proiecte:microsal:toothdesign.png?direct&100|}}
-{{:proiecte:microsal:screw.png?direct&100|}}
-Design of the casing that will hold the device. Notice the fillet that allows for the upper part removal and the hole inside the upper cap that allows for wireless signal comunication
-{{:proiecte:microsal:board.png?direct&100|}}
-PCB design of the Microsal Embedded Device. Multiple pads are present in order to have add-on connection to the sensors, after the electrical components are soldered on
 {{:proiecte:microsal:high-level.png?direct&100|}}
 {{:proiecte:microsal:protdes.png?direct&100|}}
-high lev designs of the hardware
-===== UI & Android =====
-{{:proiecte:microsal:ui.png?direct&100|}}
+high level designs of the hardware
@@ Line 55: / Line 46: @@
 **Newer iterations of the design require far smaller dimensions for the device casing, which also means less available space for the batteries and electronics.**
 The most important constraint and metric for the success of the project remains the size of the device, it must be reduced as much as possible in order to ensure user adoption. Currently, the device is large enough that teeth from lower and the upper jaw need to be sculpted in order for the device to be attached.
-\subsection{Power optimizations}
+**Power optimizations**
 For example, determine the lowest power configuration that still preserves the neuro-electro-stimulation effect. Another optimization that must be implemented is the monitoring and incorporating feedback loops from the sensors, a reasonable salivary response should not be over-stimulated. The second most important metric for the project’s success, after the device’s size, is the lifespan of the device’s battery. Naturally, a device with a longer span is to be desired, but a minimum battery life of several weeks is required in order to ensure user adoption. Note that the device cannot be recharged, as the electronic logic for charging simply cannot be integrated into such little space.
-===== Generations =====
+<hidden Generations of neurostimulator devices>
+**Generations**
 \subsection{1st Generation}
 The first generation is represented by a single project: a clunky system with a tongue suppressor probe. Although large, expensive, and somewhat not portable (While the device could run on batteries, it’s size and the size of the probe made multi-tasking hard), the device proved the effectiveness of the neuro-elecro-stimulation procedure in alleviating symptoms. As the device gave promising results in proof-of principle clinical studies and did cause any local or systemic adverse effects, it was approved by the US Food and Drug Administration in 1988 (PMA No. P860067)
@@ Line 77: / Line 69: @@
 {{:proiecte:microsal:3rd.png?direct&300|}}
 Figure shows the implantation procedure and application of the device. Transmucosal exposure of mandibular bone (A) is followed by preparation of the implant bed in mandibular bone (B) and insertion of the dental root implant (C). The neuro-electrostimulating device is shown in its applicator (D) and mounted onto the root implant (E). A radiograph of the implant-supported device is shown (F).
+</hidden>
-===== Text Dump =====
-\subsection{Waveform}
-\begin{figure}[!t]
+==== Waveform====
-\centering
-\includegraphics[width=2.5in]{waveform}
-\caption{Waveform pattern , composed of multiple sets of pulses. The sets of pulses are represented as blue and each individual pulse as green. The system works as well just in the presence of the positive front of each pulse.}
-\label{fig:waveform}
-\end{figure}
-\begin{figure}[!t]
+{{:proiecte:microsal:waveform.png?direct&100|Waveform shape}}
-\centering
-\includegraphics[width=2.5in]{protdes}
-\caption{High level design of the prototype that was used in experimentally determining which values of the signal parameters are crucial}
-\label{fig:protdes}
-\end{figure}
-\begin{figure}[!t]
+Waveform pattern , composed of multiple sets of pulses. The sets of pulses are represented as blue and each individual pulse as green. The system works as well just in the presence of the positive front of each pulse.
-\centering
-\includegraphics[width=2.5in]{UI}
-\caption{Android User Interface for the application that will communicate with the NRF51822 chip. The application is responsible for the waveform generation pattern and collecting data. The application is not bound to a particular device, it can connect to any device that match the specification}
-\label{fig:UI}
-\end{figure}
+{{:proiecte:microsal:protdes.png?direct&100|High level design of the prototype}}
-\begin{center}
+High level design of the prototype that was used in experimentally determining which values of the signal parameters are crucial
-\begin{tabular}{ |c|c|c|c|c|c|}
-\hline
+{{:proiecte:microsal:ui.png?direct&100|UI}}
-&Pulse length&Frequency&Voltage&Voltage swing&Effect\\
-\hline
+Android User Interface for the application that will communicate with the NRF51822 chip. The application is responsible for the waveform generation pattern and collecting data. The application is not bound to a particular device, it can connect to any device that match the specification
-&4 ms&0.1 Hz&	3.25 V&	positive&	N\\
-\hline
-&4 ms&1 Hz&	3 V&positive&	P\\
+==== Results from clinical test ====
-\hline
-&10 ms&1 Hz&	3 V&positive&	P\\
+^   ^  Pulse length ^ Frequency ^ Voltage ^ Voltage swing ^ Effect ^
-\hline
+|1|4 ms|0.1 Hz|3.25 V|positive|N|
-&10 ms&2 Hz&	3 V&positive&	P\\
+|2|4 ms|1 Hz|3 V|positive|P|
-\hline
+|3|10 ms|1 Hz|3 V|positive|P|
-&4 ms&4 Hz&	3 V&positive&	P\\
+|4|10 ms|2 Hz|3 V|positive|P|
-\hline
+|5|4 ms|4 Hz|3 V|positive|P|
-&4 ms&8 Hz&	3 V&positive&	P\\
+|6|4 ms|8 Hz|3 V|positive|P|
-\hline
+|7|10 ms|8 Hz|3.25 V|positive|P|
-&10 ms&8 Hz&	3.25 V&	positive&	P\\
+|8|10 ms|8 Hz|5 V|positive|P|
-\hline
+|9|10 ms|8 Hz|5 V|both |P|
-&10 ms&8 Hz&	5 V&positive&	P\\
-\hline
-&10 ms&8 Hz&	5 V&both &	P\\
-\hline
-\end{tabular}
-Table 1
-\end{center}
 In order to have the required results, with a minimum of energy expenditure we set out to find a signal pattern that produces a measurable response.
 We started by describing all possible signal parameters (see the waveform explanatory image), and implementing the control hardware and software in order to enable all of them. We considered that a sinusoid approximation is enough to stimulate the neurons without harming nearby tissue. The assumption was supported by the experiment description at [3].
-Experimentally (table 1) we determined that the patient responds favorably to a wide range of stimulation patterns, the one notable difference being when we used a combination of low pulse duration, low frequency, and low voltage. These results will be applied in the power optimization phase of the next iteration).
+Experimentally (table above) we determined that the patient responds favorably to a wide range of stimulation patterns, the one notable difference being when we used a combination of low pulse duration, low frequency, and low voltage. These results will be applied in the power optimization phase of the next iteration).
+==== Dimensions and casing====
-\subsection{Dimensions and casing}
 The device, once soldered will be stored in a bio-compatible metal cylinder casing, designed to provide protection and support. The casing will be attached similarly of a dental implant, inside the bone of the patient (3rd generation neuroelectrostimulation device). The casing is designed to provide the support and function of a real tooth, while not obstructing wireless communication.
+{{:proiecte:microsal:screw.png?direct&100|}}
-===== Bib ======
+Design of the casing that will hold the device. Notice the fillet that allows for the upper part removal and the hole inside the upper cap that allows for wireless signal comunication
-\begin{thebibliography}{1}
+{{:proiecte:microsal:board.png?direct&100|}}
+PCB design of the Microsal Embedded Device. Multiple pads are present in order to have add-on connection to the sensors, after the electrical components are soldered on
+===== Bibliography ======
-\bibitem{workshop}
 Workshop București 28.10.2016 Abordarea interdisciplinara a pacientului cu xerostomie; perspective actuale de diagnostic si tratament, PIM ed., Iasi, Romania, 2016. ISBN 978-606-13-3276-2.
-\bibitem{embeddedConf}
 Adrian Nitu, Dan Tudose, Dan Dragomir. (2016, Aug). Dental Implant With Contact Nano-Sensors for the Treatment of Xerostomia. Presented at RoEduNet
-\bibitem{electrostim}
 E. E. Harold Warner, E. David Martin, V. Speck, B. Nathan,  “Electrostimulation of erection and ejaculation and collection of semen in spinal cord injured humans”, http://www.rehab.research.va.gov/ jour/86/23/3/pdf/warner.pdf, July 1986.
-\bibitem{saliv_pacemaker}
 Porter SR, Konttinen YT. Fedele S1, Wolff A, Strietzel F, López RM. Neuroelectrostimulation in treatment of hyposalivation and xerostomia in sjögren’s syndrome: a salivary pacemaker. http://www.ncbi.nlm.nih.gov/pubmed/18671323, August 2008.
-\end{thebibliography}
+===== Working on ======
+==== UI improve ====
+Current pain points:
+  * create profiles for the stimulation parameters for each patient
+  * add UI method other than typing to update stimulation parameters
+  * create number of repetitions linked with TT
+  * draw how the signal will look
+  * show all patients, even the inactive ones
+  * tabbed ui for patients
+{{ :proiecte:microsal:75_ui.png?direct&200 |}}
+==== Refactor the characteristics ====
+Current pain points:
+    * add a time characteristic
+    * add historical data download characteristic, with pair ack characteristic
+      * will use a compression scheme
@@ Line 161: / Line 157: @@
 | Week 6 (6.2-12.2)| Created wiki page |        |
 | :::              | Discussions about future features with Dan Dragomir |  :::  |
+| Week 10 (6.3-12.3)| Sync -- Research direction meeting with DD|        |
+| :::              | Wiki -- Updated wiki page with the next features |  :::  |
+| :::              | Android UI -- Refactored Lookup activity to display all patients, improved the internal design of the application |  :::  |
+| :::              | UI redesign at 25% |  :::  |
+| Week 12 (20.3-26.3)| Android UI -- Refactored Tooth Options Activity to render how the signal will look, improved the internal design of the application|        |
+| :::              | UI redesign at 75% |  :::  |
 ===== Resources =====
 https://github.com/deathmeek/dintisor

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